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Broncos vs. Chiefs prediction: NFL Week 1 picks, odds, best bets for 'Monday Night Football'

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Published on 2026-09-14 20:30:00
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Broncos vs. Chiefs prediction: NFL Week 1 picks, odds, best bets for 'Monday Night Football'

Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information. For most of his career, Patrick Mahomes seemed almost invincible.

Just when you thought he’d take a sack, he’d scramble away and pull off one of his signature sidearm throws. If the Chiefs trailed late, even in the Super Bowl, he managed to pull off a game-winning drive to seal a win for Kansas City.

That air of invincibility first took a hit when the Chiefs were throttled 40-22 by the Eagles in Super Bowl 59. It was shaken as the Chiefs struggled to win game after game down the stretch last season and it completely shattered when Mahomes injured his knee against the Chargers, effectively ending his season.

That makes the “Monday Night Football” matchup between the Broncos and Chiefs one of the biggest regular-season games of his NFL career.

Whether he can quickly return to form, or close to it, in his first game back from injury will be the biggest question entering the game and the Broncos will test him at every turn.

The Chiefs enter the game as short 2.5-point favorites across the market with the Over/Under hovering at ...

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