Motile vesicles (MoVes) are a previously undescribed population of large extracellular vesicles released from the trailing edge of actively migrating cancer cells. MoVes carry the entire genome and mutational landscape of the parental tumour cell, together with intracellular organelles, including mitochondria, and proteins associated with epithelial-to-mesenchymal transition and organelle biology.
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References
Al-Nedawi, K. et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 10, 619–624 (2008). This paper reports the transfer of oncogenic material between cells via tumour-derived microvesicles.
van Niel, G., D’Angelo, G. & Raposo, G. Shedding light on the cell biolog...