Gut bacteria producing natural GLP-1 may induce fat loss and regulate blood sugar

Scientists have identified a bacterial strain called Ruminococcus torques that produces proteins resembling the exercise hormone irisin, which promotes fat breakdown. This discovery suggests a potential new avenue for treating metabolic conditions through the manipulation of gut bacteria. The study, published in Nature Microbiology, highlights two proteins, Rordep1 and Rordep2, that influence hormone levels, weight, bone health, and blood sugar regulation. Lead researcher Yong Fan from the University of Copenhagen noted that the abundance of Rordep-producing bacteria varies significantly among individuals, with higher levels correlating with lower body weight. These proteins stimulate the production of hormones such as GLP-1 and PYY while suppressing GIP, a hormone linked to weight gain, thereby promoting fat burning. Looking ahead over the next decade, the research team aims to evaluate the potential of Rordep bacteria as both preventive probiotics and therapeutic agents. They are exploring whether these bacteria can be developed into dietary supplements to combat chronic diseases or engineered into medicines targeting cardiovascular issues, obesity, diabetes, and osteoporosis. ...