Inhibiting Macropinocytosis Modifies Tumor Environment to Boost Treatment Effectiveness, Study Finds

A recent preclinical investigation conducted by researchers at Sanford Burnham Prebys, an NCI-designated Cancer Center, has demonstrated that inhibiting macropinocytosis can modify the tumor microenvironment in pancreatic cancers. This intervention reduces fibrosis and enhances immune cell infiltration, potentially improving the effectiveness of therapeutic strategies. The study highlights the significance of targeting cellular processes to reshape tumor surroundings and facilitate better treatment responses.