Illinois State Police say the first crash happened near 37th on the inbound Dan Ryan around 12:45 a.m.
Troopers responded to a two-vehicle crash and found two people injured. Both were taken to a nearby hospital, where one person later died.
All local lanes were closed and reopened around 5:30 a.m. with no other injuries being reported.
In a separate crash, troopers responded to a fatal two-car collision on the outbound Eisenhower near Austin on the City's west side.
One person was taken to the hospital where they later died.
ISP says all westbound lanes were closed until about 7 a.m. with IDOT on the scene.