Key Differences Between Rheumatoid Arthritis and Lupus

**Understanding the Differences Between Rheumatoid Arthritis and Lupus** Both rheumatoid arthritis (RA) and systemic lupus erythematosus (lupus) are autoimmune disorders that can lead to joint discomfort, fatigue, and swelling, among other symptoms. While they share some overlapping features, these conditions differ significantly in their affected organs, symptom severity, diagnostic processes, and treatment approaches. **Key Symptoms Comparison** | Symptom | Rheumatoid Arthritis | Lupus | |---|---|---| | Joint pain, stiffness, swelling | Common | Common | | Joint damage and deformity | Frequently occurs | Rare | | Fatigue | Present | Present | | Brain fog | Present | Present | | Dry or painful eyes | Sometimes | Common | | Skin rashes, including butterfly rash | Rare | Common | | Mouth sores | No | Yes | | Lung issues like chest pain | Possible | Possible | | Kidney inflammation | No | Yes, can lead to serious complications | | Headaches, seizures | No | Yes | **Distinctive Features** Rheumatoid arthritis mainly targets joints, particularly in the wrists and small joints of the hands and feet, often symmetrically. It can cause persistent joint damage if untreated. Lupus, howeve...