By Zac Wassink ,
1 hours ago
San Francisco 49ers defensive end Nick Bosa. Members of the San Francisco 49ers were flying high after the club began the season with impressive back-to-back wins.
However, it appears that the 49ers received a tough break ahead of their home game versus the 1-1 Arizona Cardinals this coming Sunday.
How long could 49ers be without Nick Bosa? According to NFL Network insider Ian Rapoport and ESPN's Adam Schefter , 49ers star pass-rusher Nick Bosa "is expected to miss multiple weeks after suffering a calf injury in practice this week." Rapoport and Schefter confirmed that Bosa will not play against the Cardinals.
"It remains to be seen if [Bosa] will be placed on injured reserve," Rapoport and Schefter added. Bosa would miss a minimum of four straight games while on IR.
Bosa had been attempting to reclaim his best form amid his return from t he season-ending ACL tear he suffered on Sept. 21, 2025. More recently, he dealt with tendinitis in his surgically repaired knee this past summer. While he played in the 49ers' first two games of the campaign, he did not record a sack in those contests.
Per Myles Simmons of Pro Football Talk, Bosa has tallied seven tot...